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故事发生在一间位于迈阿密的急症抢救中心内。马修（杰瑞米·诺森 Jeremy Northam 饰）在退役后来到了急症中心内，成为了这里新的一员。和马修一起工作的有马瑞索（拉娜·帕瑞拉 Lana Parrilla 饰）、克里斯托弗（迈克·沃格尔 Mike Vogel 饰）和赛琳娜（伊莉莎白·哈诺伊斯 Elisabeth Harnois 饰）等人。马瑞索是一个一心扑在手术室里的女强人，卡里斯托弗则和她恰恰相反，工作之余是一个作风放浪的花花公子。 每一天，急症室里都充斥着各种疑难杂症和突发事件，在这里，时间就等同于生命。无论这些医生们在日常生活中作风是如何的古怪，一旦穿上白大褂，他们便会化身成为手握生杀大权的天使。。A few months have passed since the last game. Adriana left Oscar and now he lives with Gaby...and Mica. Valentin came out of the closet and is trying to be happy in this new stage of his life. Barbara and Leo were stripped of their belongings by Aurelia's lawsuit but they adopted Carmen and now have a "throuple."。Dan Hawk, an ex-detective turned writer, is re-instated onto the force after returning to his home town. A serial killer has 'donned the guise' of Hawks most famous book creation, and has begun to kill people off one by one.。